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Steven B. Hoath, MD; Jayaraman Lakshmanan, PhD; Delbert A. Fisher, MD

Am J Dis Child. 1984;138(3):251-253.

Abstract
• We have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (T₄) or triiodothyronine (T₃). The results of the present study indicate similar activity of other levorotatory iodothyronine analogues and suggest the following scale of decreasing potency: T₃, trilodothyroacetic acid, triiodothyropropionic acid, T₄, reverse T₃, and diiodothyronine. Metabolically inactive analogues (reverse T₃, diiodothyronine) have no effect on skin EGF levels. A similar response pattern was observed in the adult, female mouse submandibular gland, except that T₄ seemed relatively more effective.

(AJDC 1984;138:251-253)

Author Affiliations
From the Perinatal Research Laboratories, Harbor-UCLA Medical Center, Torrance, Calif.

Footnotes
Reprint requests to Perinatal Research Laboratories, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509 (Dr Hoath).

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