 |
|
Prevalence of T-Lymphocyte Abnormalities in Infants With Congenital Heart Disease
Ernest A. Kiel, MD;
Willa H. Drummond, MD;
Douglas J. Barrett, MD
Am J Dis Child. 1984;138(2):143-146.
Abstract
| |
• Thirty-two infants younger than 6 months with catheterization-proved congenital heart disease were prospectively examined for T-lymphocyte immunodeficiency (compared with adult and normal newborn controls). Cardiac lesions were separated into two groups: (1) "high-risk" lesions previously associated with T-cell abnormalities in DiGeorge's syndrome, and (2) the remaining "low-risk" lesions. Cardiac patients as a whole did not have significant abnormalities in T-cell rosette (TCR) percentages (mean ± SE, 50.0%±22%) or response to phytohemagglutinin (PHA) (72,243±38,388 counts per minute). However, a greater percentage of patients with high-risk cardiac lesions had abnormal TCR and PHA results than either the control or low-risk group, due to the inclusion of three infants with DiGeorge's syndrome. These findings suggest that newborn infants without evidence of DiGeorge's syndrome have normal T-lymphocyte function. Infants with high-risk cardiac lesions deserve a careful immunologic evaluation to avoid significant morbidity and mortality.
(AJDC 1984;138:143-146)
Author Affiliations
From the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock (Dr Kiel); and the Departments of Pediatrics (Drs Drummond and Barrett) and Physiology (Dr Drummond), University of Florida College of Medicine, Shands Teaching Hospital, Gainesville.
Footnotes
Reprint requests to Department of Pediatrics, Division of Pediatric Cardiology, University of Arkansas for Medical Sciences, 4301W Markham St, Little Rock, AR 72205 (Dr Kiel).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Di-George syndrome presenting with hypocalcaemia in adulthood: two case reports and a review
Kar et al.
J. Clin. Pathol. 2005;58:655-657.
ABSTRACT
| FULL TEXT
|
