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Two Cases Associated With Mild Renal Insufficiency

Arieh Yarom, MD; Rob M. Rennebohm, MD; C. Frederic Strife, MD; Joseph E. Levinson, MD

Am J Dis Child. 1984;138(10):955-957.

Abstract
• Two patients had onset of juvenile gouty arthritis at ages 16 and 1 years, respectively. Both had mild renal insufficiency, with creatinine clearances of 46 and 54 mL/min/1.73 sq m, respectively. Their presenting hyperuricemia (13.8 and 11 mg/dL, respectively) was out of proportion to the degree of renal insufficiency. Clinical and laboratory studies did not suggest an inborn error of purine metabolism, glycogen storage disease type I, or any myeloproliferative disorder. Neither patient had a family history of gout or inherited renal disease. Although juvenile gouty arthritis is rare, it must be considered in the differential diagnosis of episodic arthritis in children, especially if renal impairment, even mild, is present.

(AJDC 1984;138:955-957)

Author Affiliations
From the Special Treatment Center for Juvenile Arthritis, Children's Hospital Medical Center (Drs Yarom, Rennebohm, and Levinson), and the Division of Nephrology, Children's Hospital Research Foundation (Dr Strife), Cincinnati.

Footnotes
Reprint requests to Special Treatment Center for Juvenile Arthritis, Children's Hospital Medical Center, Elland and Bethesda avenues, Pavilion Bldg 1-29, Cincinnati, OH 45229 (Dr Yarom).

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