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Continuous Naloxone Infusion in Pediatric Narcotic Overdose
James M. Lewis, MD;
Wendy Klein-Schwartz, PharmD;
Blaine E. Benson, PharmD;
Gary M. Oderda, PharmD, MPH;
Sandra Takai, MD
Am J Dis Child. 1984;138(10):944-946.
Abstract
• A 31-month-old girl required constant intravenous (IV) infusion of naloxone hydrochloride to treat codeineinduced respiratory and CNS depression. The infusion rate was 0.4 mg/hr (27 µg/kg/hr) over nine hours, without apparent side effects or evidence of toxic effects, for a total naloxone hydrochloride dose of 4.1 mg (280 µg/kg). Constant naloxone hydrochloride infusion at an initial rate of 0.4 mg/hr in pediatric narcotic poisoning should be considered if the patient responds inadequately to an initial 0.01-mg/kg bolus, requires repeated administration to reverse narcotic-induced effects, or has ingested long-acting agents. Continuous IV naloxone infusion is a convenient, safe, and effective method to treat narcotic overdose.
(AJDC 1984;138:944-946)
Author Affiliations
From the Departments of Pediatrics, University of Maryland School of Medicine (Dr Lewis) and Sinai Hospital of Baltimore (Dr Takai), and the Maryland Poison Center, University of Maryland School of Pharmacy (Drs Klein-Schwartz, Benson, and Oderda), Baltimore. Dr Lewis is now with the Marshall University School of Medicine, Huntington, WVa.
Footnotes
Reprint requests to Department of Pediatrics, Marshall University School of Medicine, 1801 Sixth Ave, Huntington, WV 25701 (Dr Lewis).
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