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Report of Cases and Review of Literature on Renal Candidiasis in Infancy

Lakshmi D. Pappu, MD; Dilip M. Purohit, MD; Barbara F. Bradford, MD; William R. Turner, Jr, MD; Abner H. Levkoff, MD

Am J Dis Child. 1984;138(10):923-926.

Abstract
• Primary renal candidiasis and hydronephrosis were diagnosed in two premature neonates in whom systemic hypertension developed. The clinical course in these patients and in 16 patients with renal candidiasis described in the literature indicated that prematurity, use of broad-spectrum antibiotics, and use of intravenous (IV) catheters are predisposing factors. Anuria and flank mass were the initial manifestations in the reviewed cases. Only four of the 16 patients survived following either antifungal therapy or nephrectomy. Both of our patients survived after antifungal therapy with amphotericin B and flucytosine for systemic effect as well as topical instillation of amphotericin B solution via a nephrostomy. We believe that a high index of suspicion in infants at risk and early institution of antifungal therapy for systemic as well as topical effect can improve the outcome in infants with renal candidiasis.

(AJDC 1984;138:923-926)

Author Affiliations
From the Departments of Pediatrics (Drs Pappu, Purohit, and Levkoff), Pediatric Radiology (Dr Bradford), and Urology (Dr Turner), Medical University of South Carolina, Charleston.

Footnotes
Reprint requests to Department of Pediatrics, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425 (Dr Pappu).

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