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A Double-blind Study

Jayne Henly Antony, MD, FRACP; Simon H. B. Hawke, MBBS

Am J Dis Child. 1983;137(9):892-895.

Abstract
• In a double-blind trial, children who had recurrent and/or complex febrile convulsions were treated with either phenobarbital sodium or carbamazepine. Forty children were suitable for analysis; 19 were receiving carbamazepine, and 21 were receiving phenobarbital. Of the carbamazepine-treated patients, nine (47%) had recurrent convulsions despite therapeutic levels of the drug, while only two (10%) of the phenobarbital-treated patients suffered further seizures. These results confirm previous findings suggesting that carbamazepine is not as effective in the prophylactic treatment of febrile convulsions as phenobarbital.

(Am J Dis Child 1983;137:892-895)

Author Affiliations
From the TY Nelson Department of Neurology and Neurosurgery, Royal Alexandra Hospital for Children, Sydney, Australia (Dr Antony), and the University of Sydney, Australia (Dr Hawke).

Footnotes
Reprint requests to TY Nelson Department of Neurology and Neurosurgery, Royal Alexandra Hospital for Children, Bridge Road, Sydney, Australia 2050 (Dr Antony).

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