 |
|
Virilizing Adrenal Adenoma in a 2-Year-Old GirlAnalysis of Tumor Steroids Using High-Performance Liquid Chromatography
Gail E. Richards, MD;
Marilyn D. Griffiths, MD;
Dennis J. Hoelzer, MD;
Michael J. Kessler, PhD;
Maria Dan, MD;
Robert N. Marshall, MD;
Louis E. Pottkotter, MD
Am J Dis Child. 1983;137(8):741-744.
Abstract
• A 2-year-old girl with virilization had an adrenal tumor that produced testosterone with little evidence of excessive urinary androgen excretion. Plasma testosterone concentration was 407 ng/dL and urinary 17-ketosteroid (17KS) levels were 3 and 2 mg/day. Excretion of 17KS decreased to 1.8 mg/day after suppression of dexamethasone therapy, but urinary 17-hydroxycorticosteroid excretion did not change from 1.0 to 0.7 mg/day after administration of dexamethasone. She had a blunted response to administration of metyrapone and insulin and a small diurnal variation in cortisol concentration suggesting suppression of corticotropin secretion, even though the plasma cortisol concentration was in the normal range and there were no clinical signs of cortisol excess. High-performance liquid chromatography was used to analyze the steroid content of tumor tissue. Those portions of the tumor that were rich in steroids contained predominantly testosterone.
(Am J Dis Child 1983;137:741-744)
Author Affiliations
From the Departments of Pediatrics (Drs Richards, Griffiths, and Marshall), Surgery (Dr Hoelzer), Pathology (Dr Dan), and Reproductive Medicine and Biology (Dr Kessler), University of Texas Medical School at Houston; Dr Pottkotter is in private practice in Houston. Dr Richards is now with the University of Texas Medical Branch, Galveston.
Footnotes
Reprint requests to Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77550 (Dr Richards).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Virilization of a Female Infant due to an Adrenal Tumor
Pardo
CLIN PEDIATR 1986;25:456-458.
ABSTRACT
|
