This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Fulminant Presentation in a Premature Infant

Martin Keszler, MD; Kolinjavadi N. Sivasubramanian, MD

Am J Dis Child. 1983;137(8):738-740.

Abstract
• Shortly after birth, a 1,860-g premature male newborn with respiratory distress syndrome had brisk diuresis, rapid weight loss, and severe hyponatremia despite aggressive Na and fluid replacement. The serum cortisol level was normal, and the 17-OH progesterone concentration was low. He did not show any response to treatment with dexamethasone and desoxycorticosterone acetate. Results of renal function studies were within the normal range for his gestational age. The serum aldosterone level and plasma renin activity were grossly elevated, confirming the diagnosis of pseudohypoaldosteronism. This uniquely early and dramatic presentation was attributed to immaturity of the proximal renal tubule at 32 weeks' gestation. The subsequent improvement paralleled the rapid maturation of the kidney after birth.

(Am J Dis Child 1983;137:738-740)

Author Affiliations
From the Division of Neonatology, Georgetown University Medical Center, Washington, DC.

Footnotes
Reprint requests to Division of Neonatology, Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (Dr Keszler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Mechanisms of ENaC Regulation and Clinical Implications
Bhalla and Hallows
J. Am. Soc. Nephrol. 2008;19:1845-1854.
ABSTRACT | FULL TEXT