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Pharmacokinetic and Therapeutic Comparison of Two Preparations

Rogelio Menendez, MD; H. William Kelly, PharmD; Jaime Howick, BPharm; Bennie C. McWilliams, MD

Am J Dis Child. 1983;137(5):469-473.

Abstract
• The serum theophylline concentration profiles and clinical efficacy of two sustained-release theophylline tablets (Quibron-T/SR and Theo-Dur) were compared in 13 asthmatic children requiring continuous theophylline therapy. Quibron-T/SR and Theo-Dur, administered every 12 hours in the same dose for one week, were evaluated in a multiple-dose randomized crossover study. At the end of each week, serial serum theophylline concentrations were measured and spirometry and body plethysmography were performed. No significant differ

Author Affiliations
From the Department of Pediatrics (Drs Menendez and McWilliams) and the School of Pharmacy (Dr Kelly and Ms Howick), University of New Mexico, Albuquerque.

Footnotes
Reprint requests to Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131 (Dr Menendez).

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