'Recurrent' Erythroblastopenia of Childhood: An IgM-Mediated RBC Aplasia

doi:10.1001/archpedi.1983.02140310040011

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Vol. 137 No. 5, May 1983

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'Recurrent' Erythroblastopenia of Childhood

An IgM-Mediated RBC Aplasia

Melvin H. Freedman, MD, FRCP(C)

Am J Dis Child. 1983;137(5):458-460.

Abstract

• An anemia of childhood with reticulocytopenia and marrowRBC aplasia was found to be due to immune-mediated erythropoieticsuppression. In vitro assays of marrow and peripheral blooderythroid progenitors indicated normal cell numbers that markedlydeclined when autologous serum or IgM was added to the cultures,but remained unchanged with autologous IgG or with autologousserum depleted of IgM. In contrast to "transient" erythroblastopeniaof childhood, this anemia was recurrent, lasted longer, andseemed to be prednisone responsive.

(Am J Dis Child 1983;137:458-460)

Author Affiliations

From the Division of Hematology, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.

Footnotes

Reprint requests to Hospital for Sick Children, 555 UniversityAve, Toronto, Ontario, Canada M5G 1X8 (Dr Freedman).

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