 |
|
Chronic Diarrhea Associated With Clostridium difficile in Children
James L. Sutphen, MD;
Richard J. Grand, MD;
Alejandro Flores, MD;
TeWan Chang, MD;
John G. Bartlett, MD
Am J Dis Child. 1983;137(3):275-278.
Abstract
• Clostridium difficile toxin was associated with chronic diarrhea without classic symptoms of colitis in seven children (age range, 7 weeks to 7 years). All patients had received antibiotics. Six of the seven were treated with vancomycin hydrochloride and demonstrated improvement. After treatment, four patients suffered relapses, and three required further therapy. One patient had four relapses. During all clinical relapses, toxin reappeared in the stool; recovery was always associated with its disappearance. Fifty-six percent of family contacts examined had positive cultures. These findings document C difficile as a probable cause of chronic diarrhea in childhood and emphasize its infectious potential.
(Am J Dis Child 1983;137:275-278)
Author Affiliations
From the Departments of Pediatrics, University of Virginia, Charlottesville (Dr Sutphen) and Harvard Medical School, Boston (Drs Grand and Flores) and the Departments of Medicine, Tufts University Medical School, (Dr Chang), Boston, and Johns Hopkins Hospital, Baltimore (Dr Bartlett).
Footnotes
Reprint requests to Department of Pediatrics, University of Virginia, Charlottesville, VA 22908 (Dr Sutphen).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Colonisation and transmission of Clostridium difficile in healthy individuals examined by PCR ribotyping and pulsed-field gel electrophoresis
KATO et al.
J Med Microbiol 2001;50:720-727.
ABSTRACT
| FULL TEXT
Case 6-1994- A 31-Month-Old Girl with Fever, Diarrhea, Abdominal Distention, and Edema
LaMont and Rashid
NEJM 1994;330:420-426.
FULL TEXT
Clostridium difficile Toxin Associated with Chronic Diarrhea and Failure to Gain Weight
Liston
CLIN PEDIATR 1983;22:458-460.
ABSTRACT
|
