This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Fernando G. Cassorla, MD; David N. Finegold, MD; John S. Parks, MD, PhD; Alfred Tenore, MD; Hasina Thawerani, MD; Lester Baker, MD

Am J Dis Child. 1983;137(2):118-122.

Abstract
• Two thyrotoxic girls, aged 12 and 16 years, had a clinical picture consisting of purpuric skin rash, nephritis, pulmonary cavitation, hemoptysis, and profound anemia during antithyroid drug therapy. These major toxic manifestations prompted discontinuation of antithyroid drugs and institution of antibiotic and glucocorticoid therapy before the resolution of the severe illness. The girls eventually required ablative doses of radioactive iodine, and one of them had a thyroidectomy for the treatment of thyrotoxicosis. The skin biopsy specimen in one patient was indicative of mononuclear cell cutaneous vasculitis. After recovery, the patients had no evidence of persistent anemia, nephritis, or pulmonary parenchymal disease.

(Am J Dis Child 1983;137:118-122)

Author Affiliations
From the Divisions of Endocrinology/Diabetes (Drs Cassorla, Finegold, Parks, Tenore, and Baker) and Pathology (Dr Thawerani), The Children's Hospital of Philadelphia. Dr Cassorla is now with the National Institutes of Health, Bethesda, Md.

Footnotes
Reprint requests to Developmental Endocrinology Branch, Bldg 10, Room 10B09, National Institutes of Health, Bethesda, MD 20205 (Dr Cassorla).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?