 |
|
Endotoxemia and Hyperbilirubinemia in the Neonate
Philip K. Goldberg;
Philip J. Kozinn, MD;
Baroukh Kodsi, MD;
Ricardo Lewitis, MD;
Bruce Ackerman, MD;
Leonard Aschenbrand, MD;
Felix Feldman, MD
Am J Dis Child. 1982;136(9):845-848.
Abstract
| |
• One hundred twenty-five neonates with varying serum bilirubin levels were tested for endotoxin by the limulus amebocyte lysate (LAL) test. Neither infection nor hemolytic disease was a contributing factor to the bilirubin levels. As the serum bilirubin level rose, positive LAL tests increased in frequency until the LAL test attained 100% at a level of 13 mg/dL. Bilirubin at different concentrations did not elicit positive LAL tests in plasma or normal saline in vitro. The LAL test was positive in urine obtained by suprapubic aspiration in 50% of neonates with positive serum LAL tests. Although bilirubin and endotoxin are cleared independently by hepatic cells with different functions, a striking relationship is evident between the endotoxin and bilirubin levels in the neonate. Immaturity of physiological liver functions in the neonate plays an important role. The LAL test cannot be used as an indicator of Gram-negative sepsis in neonates with unconjugated hyperbilirubinemia.
(Am J Dis Child 1982;136:845-848)
Author Affiliations
From the Departments of Pediatrics (Drs Goldberg, Kozinn, Lewitis, Ackerman, Aschenbrand and Feldman) and Gastroenterology (Dr Kodsi), Maimonides Medical Center, and the Downstate Medical Center, State University of New York (Drs Kozinn, Kodsi, Ackerman, Aschenbrand, and Feldman), Brooklyn.
Footnotes
Reprint requests to Pediatric Research, Maimonides Medical Center, 4802 Tenth Ave, Brooklyn, NY 11219 (Dr Goldberg).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Promoter Polymorphism of the CD14 Endotoxin Receptor Gene Is Associated With Biliary Atresia and Idiopathic Neonatal Cholestasis
Shih et al.
Pediatrics 2005;116:437-441.
ABSTRACT
| FULL TEXT
|
