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F. Estelle R. Simons, MD; George H. Luciuk, MD; Keith J. Simons, PhD

Am J Dis Child. 1982;136(9):790-793.

Abstract
• Theo-Dur, a sustained-release theophylline formulation, was administered every 12 hours for three months to ten asthmatic children aged 3 to 7 years, with no evidence of adverse reaction or tolerance. There was significant temporal variation in serum theophylline concentrations. The mean difference between the peak and trough concentrations was 6.5 µg/mL (range, 3 to 14 µg/mL) in a 12-hour period. Serum theophylline concentrations correlated well with pulmonary function test results. Nine or more hours after a Theo-Dur dose, some children needed additional bronchodilator treatment and had impairment of pulmonary function. We recommend that children aged 7 years or younger who are given Theo-Dur have monitoring of predose serum theophylline concentrations, symptoms, and signs, as many will require a dose frequency greater than every 12 hours.

(Am J Dis Child 1982;136:790-793)

Author Affiliations
From the Section of Allergy and Clinical Immunology, Department of Pediatrics, the Faculty of Medicine (Drs F. Simons and Luciuk), and the Faculty of Pharmacy (Dr K. Simons), University of Manitoba, Winnipeg.

Footnotes
Reprint requests to Children's Hospital, 678 William Ave, Winnipeg, Manitoba, Canada R3E 0W1 (Dr F. Simons).

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