Transient neonatal diabetes mellitus in half sisters. A sequel
J. D. Coffey Jr and D. E. Killelea
This is a sequel to a previous report of two half sisters with transient
neonatal diabetes mellitus. In 1970, the same syndrome developed in a third
half sibling, a boy, born of the same father by his third wife. It followed
essentially the same neonatal clinical course as that of his two half
sisters. The firstborn sibling, aged 19 years, is reported to be free of
signs and symptoms of diabetes; the third born was clinically well with no
glycosuria at 9 years 3 months of age, and was reported to be in good
health at 11 years of age. In 1978, at age 15 years diabetic ketoacidosis
and coma developed in the second-born sister and she has had
insulin-dependent diabetes since that time. These cases present a unique
genetic pattern and, to our knowledge, there have been no reports of cases
of transient neonatal diabetes becoming full-blown type I insulin-dependent
diabetes mellitus later in life.
