Prepubertal gynecomastia associated with estrogen-containing hair cream
D. V. Edidin and L. L. Levitsky
Gynecomastia associated with high plasma estrogen levels was observed in a
prepubertal boy. The family initially denied ingestion or application of
any medications despite careful review of the history, but endocrinologic
findings were not consistent with endogenous estrogen production.
Persistent inquiry discovered the use of a hair cream containing
substantial amounts of estrogen. After discontinuation of its use, breast
tissue regressed and estrogen levels returned to normal. To our knowledge,
scalp inunction has not hitherto been reported as a cause of prepubertal
gynecomastia.
