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Preschool Assessment of Infants With a Patent Ductus ArteriosusComparison of Ligation and Indomethacin Therapy
T. Allen Merritt, MD;
Charlotte L. White, PhD;
Ronald W. Coen, MD;
William F. Friedman, MD;
Louis Gluck, MD;
Morton Rosenberg, MD
Am J Dis Child. 1982;136(6):507-512.
Abstract
• We report the preschool growth and development of preterm infants with problematic patent ductus arteriosus requiring either surgical ligation or indomethacin treatment in the neonatal period. Of 60 who completed longitudinal growth assessments, no differences in growth to 3 years could be demonstrated except at 18 months, when male infants who underwent surgical ligation were lighter than those treated with indomethacin. There were no significant differences in vision or hearing abnormalities except for four cases of regressed retinopathy of prematurity among the ligated infants. Developmental tests (Bayley Scales of Infant Development and the Peabody Picture Vocabulary Test) showed no group differences at preschool ages. Although psychomotor performance on the Bayley Scales in the first 1 years was significantly lower among the surgically treated infants, later analysis showed that a similar number in both treatment groups scored within the normal range. No selective short- or long-term adverse effects of indomethacin treatment could be demonstrated.
(Am J Dis Child 1982;136:507-512)
Author Affiliations
From the Division of Neonatal/Perinatal Medicine, Department of Pediatrics, University of California, San Diego (Drs Merritt, White, Coen, and Gluck); Department of Pediatrics, UCLA Health Sciences Center, Los Angeles (Dr Friedman); and Merch, Sharpe, and Dohme, Inc, West Point, Pa (Dr Rosenberg).
Footnotes
Read in part before the Royal Women's Hospital, Carlton, Australia, Nov 28, 1981.
Reprint requests to Division of Neonatal Medicine, Department of Pediatrics, University Hospital H-814-J, 225 W Dickinson St, San Diego, CA 92103 (Dr Merritt).
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ABSTRACT
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