Fetal and maternal virilization associated with pregnancy. A case report and review of the literature
D. A. Cohen, W. H. Daughaday and V. V. Weldon
A masculinized female infant was born to a mother who had virilizing signs
dating from the fourth month of pregnancy. Serum 17
alpha-hydroxyprogesterone, dehydroepiandrosterone, and testosterone levels
were all normal in the infant. Maternal testosterone level was markedly
elevated one week post partum. Dexamethasone phosphate suppression was
normal. Human chorionic gonadotropin stimulation five weeks post partum
revealed further elevation of high baseline free and total testosterone
levels. Free and total testosterone levels 30 weeks post partum were
normal, and all maternal virilizing signs had regressed with the exception
of her deepened voice. The child has had no progression of masculinization.
The mother is believed to have had a luteoma of pregnancy.
