This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Isolated Manifestation of Mosaic Trisomy 21

Arthur G. Weinberg, MD; Gloria Schiller, MT (ASCP); Joan Windmiller, MD

Am J Dis Child. 1982;136(4):310-311.

Abstract
• A phenotypically normal neonate with an unexplained leukemoid reaction had a 46,XX/47,XX, +21 karyotype limited to the hemopoietic system. Although a self-limited myeloproliferative syndrome occurs in Down's syndrome, this case confirms that an identical disorder may develop in patients with mosaic trisomy 21 and no phenotypic stigmas of Down's syndrome. Chromosome analysis is a necessary adjunct to the examination of any neonate with an unexplained leukemoid reaction. The presence of trisomy 21 should lead to conservative management, unless there is life-threatening progression of the disease.

(Am J Dis Child 1982;136:310-311)

Author Affiliations
From the University of Texas Health Science Center at Dallas (Dr Weinberg and Ms Schiller) and John Peter Smith Hospital, Fort Worth, Tex (Dr Windmiller).

Footnotes
Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Case 19-2003 - A Five-Day-Old Girl with Leukocytosis and a Worsening Rash from Birth
Wolfe et al.
NEJM 2003;348:2557-2566.
FULL TEXT  

In a Neonate with Down Syndrome: Immunophenotypic Studies
Cook et al.
CLIN PEDIATR 1989;28:132-135.
ABSTRACT  

Congenital Leuken: An Overview
Stagner
Journal of Pediatric Oncology Nursing 1986;3:19-22.