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Howard Faden, MD; Ganesh Deshpande, MD; Mauro Grossi, MD

Am J Dis Child. 1982;136(3):223-225.

Abstract
• Amikacin sulfate was given to 21 febrile children with neutropenia and cancer for 9 ± 3 days. Peak serum amikacin levels ranged between 13 and 32 µg/mL, and trough levels were consistently less than 2 µg/mL. Renal toxic effects were detected in two children (9.5%) and were extremely mild. Two additional children (16.5%) experienced mild, transient, unilateral, high-frequency hearing losses. The lack of serious renal and auditory impairment suggests that children are at less risk than adults from aminoglycoside therapy.

(Am J Dis Child 1982;136:223-225)

Author Affiliations
From the State University of New York and Children's Hospital, Buffalo.

Footnotes
Reprint requests to Division of Infectious Diseases and Virology, Children's Hospital, 219 Bryant St, Buffalo, NY 14222 (Dr Faden).

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