This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Fetuses With Adrenal Hyperplasia, 46,XXY Fetuses, and Normal Fetuses

Dennis J. Carson, MB, MRCP; Akimasa Okuno, MD; Peter A. Lee, MD, PhD; Gail Stetten, PhD; Shailaja M. Didolkar, MD; Claude J. Migeon, MD

Am J Dis Child. 1982;136(3):218-222.

Abstract
• Concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHA), DHA sulfate (DHAS), progesterone, 17-hydroxyprogesterone (17-OHP), and hydrocortisone were determined in amniotic fluid obtained at amniocentesis or at elective cesarean section. Male fetuses had significantly higher concentrations of testosterone and androstenedione than female fetuses had between 15 and 21 weeks of gestation but not near term (36 to 40 weeks). In both sexes, progesterone and 17-OHP concentrations fell and DHA, DHAS, and hydrocortisone concentrations increased significantly with advancing gestational age. Amniotic fluid 17-OHP, testosterone, DHA, and androstenedione levels from female fetuses with congenital adrenal hyperplasia (CAH) were more elevated in the second trimester than in the third. Three female fetuses at risk for CAH, but not affected, had normal steroid concentrations. Steroid concentrations from two fetuses with Klinefelter's syndrome were not abnormal.

(Am J Dis Child 1982;136:218-222)

Author Affiliations
From the Pediatric Endocrine Clinic, Departments of Pediatrics (Drs Carson, Okuno, Lee, and Migeon) and Gynecology and Obstetrics (Drs Stetten and Didolkar), Johns Hopkins University School of Medicine, and the Department of Gynecology and Obstetrics, Union Memorial Hospital (Dr Didolkar), Baltimore.

Footnotes
Reprint requests to Children's Hospital of Pittsburgh, 125 DeSoto, Pittsburgh, PA 15213 (Dr Lee).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Technical Report: Congenital Adrenal Hyperplasia
Section on Endocrinology and Committee on Genetics
Pediatrics 2000;106:1511-1518.
ABSTRACT | FULL TEXT  

Profiling Steroid Hormones in Amniotic Fluid of Midpregnancy by Routine Stable Isotope Dilution/Gas Chromatography-Mass Spectrometry: Reference Values and Concentrations in Fetuses at Risk for 21-Hydroxylase Deficiency
Wudy et al.
J. Clin. Endocrinol. Metab. 1999;84:2724-2728.
ABSTRACT | FULL TEXT  

Experiment of Nurture: Ablatio Penis at 2 Months, Sex Reassignment at 7 Months, and a Psychosexual Follow-up in Young Adulthood
Bradley et al.
Pediatrics 1998;102:9e-9.
ABSTRACT | FULL TEXT