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Steroid ResponsivenessA Predictor of the Outcome of Splenectomy in Children With Chronic Immune Thrombocytopenic Purpura
Mark E. Weinblatt, MD;
Jorge A. Ortega, MD
Am J Dis Child. 1982;136(12):1064-1066.
Abstract
• Splenectomy is curative for many children with chronic immune thrombocytopenic purpura (ITP), but not without placing them at increased risk for serious infections. To determine the reliability of a trial of corticosteroids in predicting the outcome of splenectomy, 36 children with chronic ITP were studied retrospectively. All 20 of the children with a good response to corticosteroids achieved a complete remission after splenectomy, whereas only two of 13 nonresponders exhibited a lasting benefit from surgery. Corticosteroid responsiveness was found to be a highly reliable method of correctly identifying those patients with chronic ITP who would benefit from splenectomy.
(Am J Dis Child 1982;136:1064-1066)
Author Affiliations
From the Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, and the Division of Hematology-Oncology, Childrens Hospital of Los Angeles. Dr Weinblatt is now with North Shore University Hospital, Cornell University Medical College, Manhasset, NY.
Footnotes
Reprint requests to Division of Hematology-Oncology, Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027 (Dr Ortega).
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