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Harold K. Marder, MD; Reginald C. Tsang, MBBS; George Hug, MD; Alvin C. Crawford, MD

Am J Dis Child. 1982;136(10):914-917.

Abstract
• Low plasma calcitriol (1,25-dihydroxycholecalciferol) and normal serum calcifediol (25-hydroxycholecalciferol) levels were noted during the evaluation of an 11-year-old girl with diffuse osteoporosis and pathologic fractures. The onset of osteoporosis prior to puberty and the characteristic metaphyseal location of the fractures supported the diagnosis of idiopathic juvenile osteoporosis (IJO). Treatment with calcitriol, 1.0 µg daily, was associated with bone mineral accretion and a diminished incidence of fractures. Plasma calcitriol levels returned to normal when the disease resolved following puberty. This experience suggests a relationship between calcitriol deficiency and the pathogenesis of IJO.

(Am J Dis Child 1982;136:914-917)

Author Affiliations
From the Departments of Pediatrics (Drs Marder, Tsang, and Hug) and Pediatric Orthopedic Surgery (Dr Crawford), Children's Hospital Medical Center, Cincinnati.

Footnotes
Reprint requests to Division of Nephrology, Children's Hospital Research Foundation, Cincinnati, OH 45229 (Dr Marder).

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