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A Longitudinal Follow-up Study

Saroj Saigal, MD, FRCP(C); Ola Lunyk, BScN, RN; R. P. Bryce Larke, MD; Max A. Chernesky

Am J Dis Child. 1982;136(10):896-901.

Abstract
• Infants with congenital cytomegalovirus (CMV) infection were identified through urine cultures of 15,212 consecutive neonates and studied prospectively to determine whether their neurodevelopmental and audiologic status was different from that of matched uninfected control subjects. Of 64 children with congenital CMV infection, three died, 11 could not be located for followup, one had quadriplegic cerebral palsy, and seven had varying degrees of sensorineural hearing loss. All matched control subjects were normal neurologically, and none of them had sensorineural hearing impairment. The Stanford-Binet test revealed scores within the normal range, at 3 and 5 years of age, for both children with CMV infection and matched control subjects, as did the preschool assessment (Wide Range Achievement Test) in children older than 5 years. However, in children with CMV infection, the home environment was less stimulating, discipline and punishment were more readily implemented, and behavioral problems were significantly greater than in the matched control subjects.

(Am J Dis Child 1982;136:896-901)

Author Affiliations
From the Departments of Pediatrics and Pathology (Drs Larke and Chernesky), Faculty of Health Sciences, McMaster University, Hamilton, Ontario. Dr Larke is now with the Department of Pediatrics and the Provincial Laboratory of Public Health, University of Alberta, Edmonton.

Footnotes
Reprint requests to Department of Pediatrics, McMaster University, 1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5 (Dr Saigal).

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