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Caused by Epstein-Barr Virus

Gary R. Fleisher, MD; Jan E. Paradise, MD; Evelyne T. Lennette, PhD

Am J Dis Child. 1981;135(8):699-702.

Abstract
• The usual leukocyte response in infectious mononucleosis (IM) has been established in adults but not in children. Previously, the diagnosis of IM often was difficult in childhood due to the lack of detectable heterophil antibody response in many patients. Using Epstein-Barr virus-specific serology, we have documented IM in 45 patients between 1 and 15 years of age. The mean and ranges for the total leukocytes, percent lymphocytes, and percent atypical lymphocytes are presented. These do not vary significantly with age and are similar to those reported for adolescents and adults with this illness.

(Am J Dis Child 1981;135:699-702)

Author Affiliations
From the Divisions of Infectious Diseases (Dr Fleisher), General Pediatrics (Drs Fleisher and Paradise), and Virology (Dr Lennette), The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia.

Footnotes
Reprint requests to Division of Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 (Dr Fleisher).

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