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Family History in Assessing the Risk for Progression of Mitral Valve ProlapseReport of a Kindred
Michael J. Cooper, MD;
Edward G. Abinader, MB, FRCPI
Am J Dis Child. 1981;135(7):647-649.
Abstract
Mitral valve prolapse (MVP) consists of prolapse or billowing of the mitral leaflet(s) into the left atrium during ventricular systole associated with a mid-to-late systolic click and/or a late systolic murmur. Thoracic skeletal abnormalities, progressive mitral regurgitation, ventricular arrhythmia, and sudden death have been associated with an autosomal dominant "MVP syndrome." The discovery of MVP in an asymptomatic 8-year-old boy led to a family investigation with subsequent delineation of age-related, progressive, mitral valve disease through four generations of the kindred. Although generally considered a benign syndrome, obtaining a full family history is important in assessing the risk for progression of mitral valve disease in affected family members.
(Am J Dis Child 1981;135:647-649)
Author Affiliations
From the Department of Pediatrics, Kaiser-Permanente Medical Center, Oakland, Calif (Dr Cooper), and the Heart Institute, Rothschild University Hospital, Technion Faculty of Medicine, Haifa, Israel (Dr Abinader).
Footnotes
Reprint requests to Department of Pediatrics, Kaiser-Permanente Medical Center, 280 W MacArthur Blvd, Oakland, CA 94611 (Dr Cooper).
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