This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Kindred

Michael J. Cooper, MD; Edward G. Abinader, MB, FRCPI

Am J Dis Child. 1981;135(7):647-649.

Abstract
• Mitral valve prolapse (MVP) consists of prolapse or billowing of the mitral leaflet(s) into the left atrium during ventricular systole associated with a mid-to-late systolic click and/or a late systolic murmur. Thoracic skeletal abnormalities, progressive mitral regurgitation, ventricular arrhythmia, and sudden death have been associated with an autosomal dominant "MVP syndrome." The discovery of MVP in an asymptomatic 8-year-old boy led to a family investigation with subsequent delineation of age-related, progressive, mitral valve disease through four generations of the kindred. Although generally considered a benign syndrome, obtaining a full family history is important in assessing the risk for progression of mitral valve disease in affected family members.

(Am J Dis Child 1981;135:647-649)

Author Affiliations
From the Department of Pediatrics, Kaiser-Permanente Medical Center, Oakland, Calif (Dr Cooper), and the Heart Institute, Rothschild University Hospital, Technion Faculty of Medicine, Haifa, Israel (Dr Abinader).

Footnotes
Reprint requests to Department of Pediatrics, Kaiser-Permanente Medical Center, 280 W MacArthur Blvd, Oakland, CA 94611 (Dr Cooper).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?