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  Vol. 135 No. 5, May 1981 TABLE OF CONTENTS
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Genetic Influences in the Epilepsies

Review of the Literature With Practical Implications

Mark T. Jennings, MD; Thomas D. Bird, MD

Am J Dis Child. 1981;135(5):450-457.


Abstract



• We review hereditary influences in the epilepsies from the perspective of medical genetics. The recurrence risk for epilepsy in close relatives may vary from 2% to 5% up to 50% depending on the etiology of the seizure disorder in the proband. We emphasize the identification of specific disorders with single-gene inheritance that will lead to useful conclusions regarding treatment, prognosis, and family counseling. Also discussed are chromosomal aberrations, polygenic inheritance, gene-environment interactions, animal models of epilepsy, and the pharmacogenetics of anticonvulsants.

(Am J Dis Child 1981;135:450-457)



Author Affiliations



From the Department of Medicine (Medical Genetics and Neurology), University of Washington School of Medicine (Drs Jennings and Bird), and the Veterans Administration Medical Center (Dr Bird), Seattle.


Footnotes



Reprint requests to Neurology Section, VA Medical Center, 4435 Beacon Ave S, Seattle, WA 98108 (Dr Bird).



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