Interaction of minoxidil and captopril in the treatment of refractory hypertension

J. R. Matson, L. H. Norby and J. E. Robillard

A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed. Hyperreninemic hypoaldosteronism with hyperkalemia and acidosis developed after captopril administration was started.