Furazolidone and quinacrine. Comparative study of therapy for giardiasis in children
J. C. Craft, T. Murphy and J. D. Nelson
Furazolidone and quinacrine hydrochloride were compared for efficacy,
toxicity, and ease of administration in 45 young children with giardiasis.
With the initial course of therapy, the cure rate was 89% (17/19) with
furazolidone and with quinacrine it was 64% (9/14) in children less than 5
years and 92% (11/12) in older children. Cure rates for all courses of
therapy were 92% (24/26) with furazolidone and 53% (9/17) and 92% (12/13)
in the younger and older children, respectively, treated with quinacrine.
Quinacrine failure was usually due to severe vomiting. When re-treated with
furazolidone, patients were cured. The disadvantages of furazolidone are
the large volume of doses and the expense. In this study, furazolidone was
more effective and better tolerated than quinacrine for the treatment of
giardiasis.
