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Hyperthyroidism in ChildrenA Reevaluation of Treatment
Bruce A. Buckingham, MD;
Gertrude Costin, MD;
Thomas F. Roe, MD;
Jordan J. Weitzman, MD;
Maurice D. Kogut, MD
Am J Dis Child. 1981;135(2):112-117.
Abstract
• The results of medical and surgical therapy were determined in 107 hyperthyroid children. After surgery, 85% of patients were rendered free of hyperthyroidism; however, 62% became hypothyroid. After medical treatment, 30% of patients were euthyroid and 2% became hypothyroid. The relapse rate, however, was higher after medical (22%) than after surgical (9%) therapy. Serious drug-related complications (arthritis-, hepatitis-, and collagen disease-like syndromes) occurred in 14% of patients. Complications occurred in 9% of surgically treated patients, but recurrent laryngeal nerve injury or permanent hypoparathyroidism did not occur. In medically treated patients, both a goiter size less than three times normal prior to treatment and a reduction in goiter size to less than two times normal at the completion of therapy correlated with a successful outcome.
(Am J Dis Child 1981;135:112-117)
Author Affiliations
From the Division of Endocrinology and Metabolism, Department of Pediatrics (Drs Buckingham, Costin, Roe, and Kogut), and the Division of Pediatric Surgery, Department of Surgery (Dr Weitzman), Childrens Hospital of Los Angeles; and the University of Southern California School of Medicine, Los Angeles.
Footnotes
Reprint requests to Childrens Hospital of Orange County, 1109 W La Veta Ave, Orange, CA 92668 (Dr Buckingham).
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