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Thomas W. Rowland, MD; Leif G. Nordstrom, MD; Mark S. Bean, MD; Henry Burkhardt, MD

Am J Dis Child. 1981;135(11):1050-1052.

Abstract
• Precocious pulmonary hypertension in children with Down's syndrome may occur in patients with or without congenital heart disease. Chronic upper airway obstruction, which is common in Down's syndrome, is a well-recognized stimulus of elevated pulmonary artery pressure and may explain the propensity for idiopathic pulmonary hypertension or accelerated pulmonary vascular changes with left-to-right shunts in these children.

(Am J Dis Child 1981;135:1050-1052)

Author Affiliations
From the Departments of Pediatrics (Drs Rowland, Nordstrom, and Burkhardt) and Radiology (Dr Bean), Baystate Medical Center, Springfield, Mass.

Footnotes
Reprint requests to Department of Pediatrics, Baystate Medical Center, 759 Chestnut St, Springfield, MA 01107 (Dr Rowland).

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