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Management of Recurrent Invasive Haemophilus influenzae Infection
Lazar Fruchter, MD;
Richard Insel, MD
Am J Dis Child. 1981;135(10):927-929.
Abstract
• A 4 -month-old infant had three separate episodes of invasive Haemophilus influenzae type b infection and did not produce antibody to the capsular polysaccharide of H influenzae b. Immunologic evaluation disclosed normal immunoglobulin and complement concentrations and normal T-cell number and function. In view of the persistent presence of type-specific capsular polysaccharide of H influenzae b (polyribophosphate [PRP]) in blood serum without any detectable anti-PRP antibody for 30 days following H influenzae b meningitis, monthly treatment with immune human serum globulin was undertaken until spontaneous production of anti-PRP antibody occurred. The patient's 4-year-old sibling was found to be a nasopharyngeal carrier and may have been a source for reinfection. A search for possible family carriers should be conducted in evaluating the conditions of patients with recurrent invasive H influenzae b infection. In addition, temporary treatment with immune human serum globulin should be considered.
(Am J Dis Child 1981;135:927-929)
Author Affiliations
From the Division of Pediatric Allergy and Immunology, Department of Pediatrics, Long Island Jewish-Hillside Medical Center, New Hyde Park, NY (Dr Fruchter); Department of Pediatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook (Dr Fruchter); and Division of Infectious Diseases and Immunology, Department of Pediatrics, University of Rochester (NY) School of Medicine and Dentistry (Dr Insel).
Footnotes
Reprint requests to Department of Pediatrics, Long Island Jewish-Hillside Medical Center, New Hyde Park, NY 11042 (Dr Fruchter).
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