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  Vol. 135 No. 10, October 1981 TABLE OF CONTENTS
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Management of recurrent invasive Haemophilus influenzae infection

L. Fruchter and R. Insel

A 4 1/2-month-old infant had three separate episodes of invasive Haemophilus influenzae type b infection and did not produce antibody to the capsular polysaccharide of H influenzae b. Immunologic evaluation disclosed normal immunoglobulin and complement concentrations and normal T-cell number and function. In view of the persistent presence of type-specific capsular polysaccharide of H influenzae b (polyribophosphate [PRP]) in blood serum without any detectable anti-PRP antibody for 30 days following H influenzae b meningitis, monthly treatment with immune human serum globulin was undertaken until spontaneous production of anti-PRP antibody occurred. The patient's 4-year-old sibling was found to be a nasopharyngeal carrier and may have been a source for reinfection. A search for possible family carriers should be conducted in evaluating the conditions of patients with recurrent invasive H influenzae b infection. In addition, temporary treatment with immune human serum globulin should be considered.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pathogenesis and Prevention of Recurrent Infection After Haemophilus influenzae Bacteremia
Liston
CLIN PEDIATR 1984;23:215-219.
ABSTRACT  





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