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Dennis C. Stokes, MD; John T. McBride, MD; Michael A. Wall, MD; Giuseppe Erba, MD; Denise J. Strieder, MD

Am J Dis Child. 1980;134(8):741-743.

Abstract
• Hypoxemia, obstructive apnea, and disordered breathing during sleep have been documented in adult patients with chronic obstructive pulmonary disease. We studied sleep, oxygen saturation, and breathing in nine patients (ages 17 to 26 years) with cystic fibrosis (CF) lung disease by means of all-night polygraphic tracings. Two had brief episodes of oxygen desaturation during rapid eye movement (REM) sleep, and one patient with severe disease had prolonged desaturation with episodic worsening associated with disordered breathing in REM sleep and with cough. No patient had apnea or any evidence of upper airway obstruction, in contrast with studies of older patients. In three patients, nocturnal coughing contributed to disruption of sleep cycles. Sleep oxygen desaturation may contribute to the development or progression of cor pulmonale in some patients with CF, but it seems to be most severe only in those with advanced disease.

(Am J Dis Child 134:741-743, 1980)

Author Affiliations
From the Departments of Medicine (Drs Stokes, McBride, Wall, and Strieder) and Neurology (Dr Erba), Children's Hospital Medical Center and the Department of Pediatrics (Drs Stokes, McBride, Wall, and Strieder), Harvard Medical School, Boston. Dr Stokes is presently with the Department of Pediatrics, Johns Hopkins Hospital, Baltimore; Dr Wall is presently with the Department of Pediatrics, University of Oregon Health Sciences Center, Portland.

Footnotes
Reprint requests to Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD 21205 (Dr Stokes).

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