This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Its Occurrence During Sleep in Patients With Cystic Fibrosis

Paul W. J. Francis, MB, BS, FRACP; Nestor L. Muller, MD; Dennis Gurwitz, MB, BCh, FRCP(C); David W. A. Milligan, MB, BS, MRCP; Henry Levison, MD; A. Charles Bryan, MB, BS, PhD, FRCP(C)

Am J Dis Child. 1980;134(8):734-740.

Abstract
• Sleep studies were performed in 20 clinically stable cystic fibrosis (CF) patients (mean age, 18.2 years) to determine the magnitude of fall in hemoglobin saturation (Sao₂) during sleep and to relate these changes to pulmonary function and echocardiographic findings. Five healthy young adults served as controls. In both groups, the maximum fall in Sao₂ was seen during rapid eye movement (REM) sleep. The mean maximum fall in the control group during REM sleep was 2.0% (range, 1% to 3%), compared with 7.4% (range, 1% to 23%) in the CF group. Of the 11 patients in whom right ventricular systolic time intervals were obtained, eight of the nine patients with falls in Sao₂ greater than 3% during REM sleep had echocardiographic evidence of pulmonary hypertension. Repeated episodes of desaturation during sleep may contribute to the development and progression of cor pulmonale in CF patients.

(Am J Dis Child 134:734-740, 1980)

Author Affiliations
From the Division of Respiratory Physiology, Research Institute, Hospital for Sick Children, Toronto.

Footnotes
Reprint requests to Pulmonary Function Laboratory, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8 (Dr Levison).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sleep-Related Hypoventilation/Hypoxemic Syndromes
Casey et al.
Chest 2007;131:1936-1948.
ABSTRACT | FULL TEXT  

The Relationship Between Sleep Disturbance and Pulmonary Function in Stable Pediatric Cystic Fibrosis Patients
Amin et al.
Chest 2005;128:1357-1363.
ABSTRACT | FULL TEXT  

Cystic Fibrosis Patients Have Poor Sleep Quality Despite Normal Sleep Latency and Efficiency
Jankelowitz et al.
Chest 2005;127:1593-1599.
ABSTRACT | FULL TEXT  

Sleep quality and daytime function in adults with cystic fibrosis and severe lung disease
Dancey et al.
Eur Respir J 2002;19:504-510.
ABSTRACT | FULL TEXT  

Predicting Sleep-Disordered Breathing in Patients With Cystic Fibrosis
Milross et al.
Chest 2001;120:1239-1245.
ABSTRACT | FULL TEXT  

Low-flow Oxygen and Bilevel Ventilatory Support . Effects on Ventilation during Sleep in Cystic Fibrosis
MILROSS et al.
Am. J. Respir. Crit. Care Med. 2001;163:129-134.
ABSTRACT | FULL TEXT  

Nocturnal oximetry in infants with cystic fibrosis
Villa et al.
Arch. Dis. Child. 2001;84:50-54.
ABSTRACT | FULL TEXT  

Pulmonary Hypertension and Cardiac Function in Adult Cystic Fibrosis: Role of Hypoxemia
Fraser et al.
Chest 1999;115:1321-1328.
ABSTRACT | FULL TEXT