Juvenile chronic granulocytic leukemia: emphasis on cutaneous manifestations and underlying neurofibromatosis
J. A. Mays, R. C. Neerhout, G. C. Bagby and R. D. Koler
Five patients with juvenile chronic granulocytic leukemia are described.
Two patients had multiple cafe-au-lait spots compatible with von
Recklinghausen's neurofibromatosis, and three had cutaneous xanthomata.
Recurrent cutaneous leukemic infiltrates were noted in two patients. The
clinical course of all five patients was characterized by recurrent
respiratory symptoms and pulmonary infiltrates that responded to
antileukemic therapy in three. Chemotherapy controlled the symptoms but did
not influence the eventually fatal outcome.
