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Dose, Serum Level, and Toxicity

Robert A. Doughty, MD, PhD; Linda Giesecke, RN; Balu Athreya, MD

Am J Dis Child. 1980;134(5):461-463.

Abstract
• In a prospective study of aspirin therapy for 67 children with juvenile rheumatoid arthritis, we have found that (1) doses greater than 100 mg/kg/day of aspirin may be necessary to achieve therapeutic salicylate levels greater than 20 mg/dL; (2) no improvement in clinical remission rate is seen at salicylate levels greater than 30 mg/dL; (3) clinical toxicity to aspirin is of relatively low incidence (16%), and infrequently causes serious morbidity; (4) symptomatic SGOT elevations are common in the first three months after onset of therapy; and (5) these elevated SGOT levels generally return to normal despite continuation of therapy.

(Am J Dis Child 134:461-463, 1980)

Author Affiliations
From the Children's Hospital of Philadelphia; University of Pennsylvania School of Medicine, Philadelphia; and Children's Seashore House, Atlantic City, NJ.

Footnotes
Reprint requests to Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104 (Dr Doughty).

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