Serum 1,25-dihydroxyvitamin D levels in normal children and in vitamin D disorders
R. W. Chesney, J. F. Rosen, A. J. Hamstra and H. F. DeLuca
Using a precise assay for 1,25-dihydroxyvitamin D in serum, the levels in
103 children, aged 13 months to 16 years, were found to be 43 +/- 2 pg/mL
(mean +/- SE). This value is higher than reported values in adults and in
neonates. Age-related changes in 1,25-dihydroxyvitamin D levels during
childhood were also evident. Older children have significantly higher
levels than children less than 11 years, possibly indicating changes with
puberty and the adolescent growth spurt. The values were significantly
reduced in childhood uremia (13 +/- 5 pg/mL), in hypoparathyroidism (16 +/-
1 pg/mL), and in children with Fanconi's syndrome. Treatment with oral
calcitriol in these three groups of patients led to increased serum levels.
