Reye's syndrome in three siblings. Association with type A influenza infection
R. Wilson, J. Miller, H. Greene, R. Rankin, L. Lumeng, D. Gordon, D. Nelson and G. Noble
Reye's syndrome occurred simultaneously in three siblings. All had
characteristic changes in liver histology ascertained by light and electron
microscopy. The two patients with the most severe disease also had serum
that caused marked stimulation of mitochondrial state 4 respiration in
vitro. Histocompatibility locus antigen typing showed that no unique
haplotypes were shared by all three children. There was no evidence of
exposure to aflatoxins, pesticides, or other substances that have been
previously postulated to be associated with Reye's syndrome. Influenza
A/Brazil/11/78-like virus was isolated from one patient, and all three
patients had a fourfold or greater rise in hemagglutination-inhibiting
antibody to H1N1 influenza virus.
