Congenital leukemoid reaction followed by fatal leukemia. A case with Down's syndrome
H. P. Lin, H. Menaka, K. H. Lim and H. S. Yong
A serial clinical, hematologic, and cytogenetic study was done on a baby
with Down's syndrome in whom a myeloid leukemoid reaction developed at
birth that spontaneously regressed within a month only to relapse two years
later to an acute undifferentiated stem cell leukemia. He died 1 1/2 months
after onset. The unresolved controversy of the diagnosis of the congenital
leukemia-like state is discussed. The importance of following up such
patients with apparent remission of their congenital leukemia-like disorder
is emphasized.
