Incidence of meconium abnormalities in newborn infants with cystic fibrosis
B. J. Rosenstein and T. S. Langbaum
Review of the newborn nursery notes of 87 infants who had cystic fibrosis
without meconium ileus (MI) indicated that 12 of them had clinical features
consistent with the meconium plug syndrome (MPS). This high incidence of
meconium abnormalities suggests that MI and the MPS probably represent
different gradations of the same underlying pathologic abnormality. The
findings further suggest that a quantitative pilocarpine iontophoresis
sweat test be performed in every newborn infant with any type of meconium
abnormality, including the spontaneous passage of meconium plugs.
