This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Fredda Ginsberg-Fellner, MD; Elliot J. Rayfield, MD

Am J Dis Child. 1980;134(1):64-67.

Abstract
• An 8-year-old boy with a convulsive disorder for 3 years remained seizure free for 20 months while being treated with phenytoin (diphenylhydantoin) sodium, and then he had a relapse. He first demonstrated hypoglycemia when he fasted prior to being placed on a ketogenic diet. An oral glucose tolerance test indicated fasting and postglucose hypoglycemia and substantial hyperinsulinemia. Somatostatin infusion resulted in a modest increase in plasma glucose levels and a decrease in serum insulin concentrations. A discrete pancreatic mass was demonstrated preoperatively by celiac angiography that on surgical extirpation, proved to be a benign intrapancreatic insulinoma. Evaluation for islet cell tumors is of importance in children with seizure disorders unresponsive to anticonvulsant medication. Furthermore, somatostatin may be useful preoperatively in maintaining normal blood glucose concentrations in patients with islet cell adenomas.

(Am J Dis Child 134:64-67, 1980)

Author Affiliations
From the Departments of Pediatrics (Dr Ginsberg-Fellner) and Medicine (Dr Rayfield), Mount Sinai School of Medicine of the City University of New York.

Footnotes
Reprint requests to Department of Pediatrics, Mount Sinai School of Medicine, Fifth Ave and 100th St, New York, NY 10029 (Dr Ginsberg-Fellner).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?