This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Use of Continuous Sulfamethoxazole-Trimethoprim Therapy

Richard E. Harris, MD; John A. McCallister, MD; Sari A. Allen; Alexis S. Barton, RN; Robert L. Baehner, MD

Am J Dis Child. 1980;134(1):35-38.

Abstract
• Owing to a 15% attack rate of Pneumocystis carinii pneumonitis (PCP) among the leukemic population at Riley Hospital, Indianapolis, a two-year study using continuous low-dosage sulfamethoxazole-trimethoprim to prevent PCP was started in January 1977. A total of 229 pediatric cancer patients considered at high risk for getting PCP received prophylaxis, while 19 additional low-risk cancer patients did not receive sulfamethoxazole-trimethoprim. None of these 248 patients contracted PCP. However, five cases of PCP did occur among ten additional high-risk patients who failed to receive this preparation for a variety of reasons. Complications of the continuous prophylaxis program included neutropenia, rash, and gastrointestinal complaints. This study confirms that continuous, low-dosage sulfamethoxazole-trimethoprim prophylaxis is effective in preventing PCP in susceptible immunosuppressed patients but is ineffective in eradicating the organism from the population at risk.

(Am J Dis Child 134:35-38, 1980)

Author Affiliations
From the Division of Pediatric Hematology-Oncology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.

Footnotes
Reprint requests to Division of Pediatric Hematology-Oncology, Riley Hospital for Children, P-132, Indiana University School of Medicine, 1100 W Michigan St, Indianapolis, IN 46223 (Dr Harris).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Successful Intermittent Prophylaxis With Trimethoprim/Sulfamethoxazole 2 Days per Week for Pneumocystis carinii (jiroveci) Pneumonia in Pediatric Oncology Patients
Lindemulder and Albano
Pediatrics 2007;120:e47-e51.
ABSTRACT | FULL TEXT  

Chemoprophylaxis for Pneumocystis carinii Pneumonitis: Outcome of Unstructured Delivery
Wilber et al.
Arch Pediatr Adolesc Med 1980;134:643-648.
ABSTRACT