Computerized tomography in the evaluation of isosexual precocity

W. Hung, G. P. August, D. R. Brallier and T. H. Milhorat

Clinical and laboratory observations were made in three children with isosexual precocity. None of the patients showed abnormalities in neurological or visual-field examinations although one patient had arrested hydrocephalus and a head circumference greater than the 98th percentile for her age and another patient had a history of seizures. Roentgenograms of the skull were normal in all patients. Cranial computerized tomography (CT) identified a lesion in each patient. We believe that craniel CT should be performed in any patient with isosexual precocity in whom a specific cause is not evident or in whom a cerebral cause is suggested even though the patient may be otherwise normal. Cranial CT is a safe, accurate, and noninvasive technique.