Congenital glomerulosclerosis and nephrotic syndrome in two infants. Speculations and pathogenesis
M. G. Beale, D. S. Strayer, J. M. Kissane and A. M. Robson
The incidental finding of hyalinized glomeruli in otherwise normal infant
kidneys is referred to as congenital glomerulosclerosis. Two infants had
extensive glomerulosclerosis manifested by nephrotic syndrome, severe
oliguria, and progressive renal failure. Both patients were believed to
have had intrauterine infections. These two cases have unequivocally
identified congenital glomerulosclerosis as one of the causes of nephrotic
syndrome in infancy. In addition, they suggest that extensive
glomerulosclerosis in some cases may be a result of congenital infections.
