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Richard H. Sills, MD; Frank A. Oski, MD

Am J Dis Child. 1979;133(5):526-527.

Abstract
• Functional asplenia develops in children with sickle cell anemia. This asplenia is related to the increased incidence of bacterial sepsis that has been documented in these patients. With the use of direct-interference contrast microscopy to quantitate splenic function, we studied children with the sickle hemoglobinopathies. A gradual increase in splenic dysfunction with increasing age was documented in children with homozygous sickle cell disease. Children with the sickle variants also seem to manifest degrees of splenic dysfunction. Direct-interference contrast microscopy is a simple quantitative technique for the evaluation of splenic function in children with the sickle hemoglobinopathies.

(Am J Dis Child 133:526-527, 1979)

Author Affiliations
From the Department of Pediatrics, State University Hospital, Upstate Medical Center, Syracuse, NY.

Footnotes
Reprint requests to Hematology Division, Children's Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222 (Dr Sills).

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