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Case Report and Review

Gerald A. Ahronheim, MD; Beth Reich, MD; Melvin I. Marks, MD, FRCP(C)

Am J Dis Child. 1979;133(2):187-191.

Abstract
• Infections due to pneumococci with decreased susceptibility (or resistance) to penicillin have been infrequently recognized. Our experience and that of others suggest that (1) penicillin susceptibility testing of significant pneumococcal isolates should become routine; (2) penicillin may not be adequate therapy for CNS infections due to pneumococci whose penicillin minimal inhibitory concentration is > 0.1 µg/ml; and (3) long-term penicillin "prophylaxis" may be inappropriate in the splenectomized patient in areas where these organisms are prevalent.

(Am J Dis Child 133:187-191, 1979)

Author Affiliations
From the Division of Infectious Diseases, Montreal Children's Hospital, and the Department of Pediatrics, McGill University, Montreal.

Footnotes
Read in part before the 45th annual meeting of the Royal College of Physicians and Surgeons of Canada, Toronto, Jan 28, 1977.

Reprint requests to Division of Infectious Diseases, Montreal Children's Hospital, 2300 Tupper St, Montreal, Quebec, Canada H3H 1P3 (Dr Ahronheim).

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