Sensitivity of Group A Streptococci to Antibiotics: Prevalence of Resistance to Erythromycin in Japan

doi:10.1001/archpedi.1979.02130110051007

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Vol. 133 No. 11, November 1979

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Sensitivity of Group A Streptococci to Antibiotics

Prevalence of Resistance to Erythromycin in Japan

Shizuo Maruyama, MD; Hajime Yoshioka, MD; Kozo Fujita, MD; Masatoshi Takimoto, MD; Yoshio Satake, MD

Am J Dis Child. 1979;133(11):1143-1145.

Abstract

• More than 60% of all strains of group A streptococciisolated during the period from 1974 to 1975 from children withstreptococcal infections in Hokkaido district, Japan, were highlyresistant to erythromycin. These strains were found to be multiplyresistant to lincomycin hydrochloride monohydrate, chloramphenicol,and tetracycline, and were exclusively type 12 by T-proteintyping. The clinical symptoms produced by these organisms wererather mild, responded to penicillin well, and were rarely complicatedwith glomerulonephritis. The high prevalence of resistant groupA streptococci was nationwide, which may have been related torecent excessive use of erythromycin and other macrolide antibiotics.Erythromycin can no longer be considered the drug of choicein the management of streptococcal infections in Japan. Thissuggests that a periodic surveillance of antibiotic sensitivityof streptococcal isolates may be necessary in other countriesin which macrolide antibiotics are frequently prescribed.

(Am J Dis Child 133:1143-1145, 1979)

Author Affiliations

From the Departments of Pediatrics, Asahikawa Medical College (Drs Maruyama, Yoshioka, Fujita, and Takimoto) and Asahikawa City Hospital (Dr Satake), Asahikawa, Japan.

Footnotes

Reprint requests to Department of Pediatrics, Asahikawa MedicalCollege, Nishikagura 4-5-3-11, 078-11 Asahikawa, Japan (Dr Maruyama).

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