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Gerald S. Berenson, MD; Caroline V. Blonde, MD, MPH; Rosanne P. Farris, RD; Theda A. Foster, MS; Gail C. Frank, RD, MPH; Sathanur R. Srinivasan, PhD; Antonie W. Voors, MD, DPH; Larry S. Webber, PhD

Am J Dis Child. 1979;133(10):1049-1057.

Abstract
• Cardiovascular risk factor variables were measured in a cohort of 440 infants at birth, 6 months, and 1 year of age. Blood pressures at 6 months of age were 93/47 mm Hg (systolic/diastolic pressure, fourth phase) and 97/51 mm Hg at 1 year of age. Serum total cholesterol, β-lipoprotein, and -lipoprotein levels rose dramatically from birth to 1 year of age. Serum triglycerides also showed an increase from birth to 6 months of age, but a decrease from 6 months to 1 year of age. At 6 months of age, the infants were consuming 949 kcal and at 1 year, 1,356 kcal. A statistically significant correlation between serum cholesterol level and protein, fat, cholesterol, and carbohydrate intake was noted at 1 year of age. These observations provide a background for tracing the evolution of risk factor variables as part of the early natural history of arteriosclerosis.

(Am J Dis Child 133:1049-1057, 1979)

Author Affiliations
From the Departments of Medicine (Drs Berenson, Blonde, Webber, and Srinivasan, Ms Frank, and Ms Farris), Biometry (Dr Webber and Ms Foster), and Public Health and Preventive Medicine (Drs Blonde and Voors), Louisiana State University Medical Center, New Orleans.

Footnotes
Reprint requests to Department of Medicine, LSU Medical Center, 1542 Tulane Ave, New Orleans, LA 70112 (Dr Berenson).

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