Intrauterine hyperparathyroidism. Postmortem findings in two cases
C. Stuart, T. Aceto Jr, J. P. Kuhn and K. Terplan
Intrauterine hyperparathyroidism is a self-limited condition seen in the
neonate born of a mother with poorly controlled hypoparathyroidism. In this
report, we describe the histologic findings in bone and parathyroids in
twin infants with this condition who died from other causes. The skeleton
showed osteopenia with evidence of increased bone turnover and defective
mineralization, and there was parathyroid gland hyperplasia of the
water-clear cell type. One twin died at birth, and the histologic findings
were indistinguishable from those of infantile primary hyperparathyroidism;
but the second twin, dying at 3 months of age, demonstrated noticeable
improvement in the bone and parathyroid abnormalities.
