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Stephen J. Boros, MD; Anna A. Orgill, MB, ChB

Am J Dis Child. 1978;132(9):865-869.

Abstract
• The effect of pressure-limited (PL) and volume-limited (VL) ventilation on mortality and morbidity in infants with severe hyaline membrane disease (HMD) was examined in a prospective controlled study. Criteria for mechanical ventilation were Pao₂ value of 50 mm Hg or less or a Paco₂ value of 70 mm Hg or greater, while the infant was receiving nasal continuous positive airway pressure (CPAP) at oxygen concentrations (FIO₂) of 0.8 or greater and CPAP of 8 cm H₂O or greater; HMD associated with severe perinatal asphyxia requiring mechanical ventilation in the delivery room.

Consecutive patients were alternately assigned to receive either PL or VL ventilation. Twenty infants were ventilated with PL machines using low peak inspiratory pressures (mean maximum inspiratory pressure of 28 cm H₂O) and prolonged inspiratory times. Twenty other infants were ventilated with VL machines, using essentially unlimited peak inspiratory pressures (mean maximum inspiratory pressure of 62 cm H₂O) and prolonged expiratory times.

There were no significant differences in survival, incidence of pneumothorax or pulmonary interstitial emphysema, or noteworthy bronchopulmonary dysplasia.

(Am J Dis Child 132:865-869, 1978)

Author Affiliations
From the Children's Hospital, St Paul; and the Department of Pediatrics, University of Minnesota, Minneapolis.

Footnotes
Reprint requests to Children's Hospital, 311 Pleasant Ave, St Paul, MN 55102 (Dr Boros).

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